Best way to treat Blepharitis: Which is better to treat Blepharitis--Diluted Tea Tree Oil or Dilute Povidone Iodine with Dimethylsulfoxide

No one has done a head to head study yet on whether Diluted Tea Tree Oil OR Dilute Povidone Iodine with Dimethylsulfoxide is better. Likely they both achieve the job of killing demodex mites and other surface bacteria.

Blepharitis means inflammation of the eyelid margin and is usually due to Demodex mites, bacterial overgrowth, yeast colonization, viral infection, atopy, seborrhea, environmental factors, hormonal dysregulation, and/or underlying rosacea. It can destroy meibomian glands if left untreated.

Here is more about Dilute Povidone Iodine with Dimethylsulfoxide

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Abstract

Introduction

Povidone iodine (PVP-I) 10% aqueous solution is a commonly utilized anti-septic employed for sterilization of the ocular surface prior to interventional procedures. Dimethylsulfoxide (DMSO) is a well-known skin penetration agent scarcely utilized in ophthalmic drug formulations. We describe here a low-dose formulation of 1% PVP-I (w/w) in a gel containing DMSO for use in the setting of recalcitrant rosacea blepharoconjunctivitis. A review of the ocular uses of dimethylsulfoxide is also presented.

Case report

A 78-year-old male presented with chronic, long-standing blepharitis involving both the anterior and posterior lid margins. Posterior lid and skin inflammatory changes were consistent with ocular rosacea. Previous oral and topical therapies had been largely ineffective at controlling his condition.

Conclusion

The topical PVP-I/DMSO system was effective in abating the signs and symptoms of rosacea blepharoconjunctivitis. Further investigation of this novel agent is warranted.

Electronic supplementary material

The online version of this article (doi:10.1007/s40123-015-0040-4) contains supplementary material, which is available to authorized users.

Keywords: 

Ophthalmol Ther. 2015 Dec; 4(2): 143–150.

Published online 2015 Nov 2. doi:  10.1007/s40123-015-0040-4

PMCID: PMC4675729

Rosacea Blepharoconjunctivitis Treated with a Novel Preparation of Dilute Povidone Iodine and Dimethylsulfoxide: a Case Report and Review of the Literature

Jesse S. Pelletier, Kevin P. Stewart, Kara Capriotti, and Joseph A. Capriotti

ALC Therapeutics, LLC, Springhouse, PA USA

Ocean Ophthalmology Group, Miami, FL USA

Plessen Ophthalmology Consultants, Christiansted, VI USA

Bryn Mawr Skin and Cancer Institute, Rosemont, PA USA

Jesse S. Pelletier, Email: moc.oohay@reitellepessej.

Corresponding author.

Author information ▼ Article notes ► Copyright and License information ▼

Abstract

Introduction

Povidone iodine (PVP-I) 10% aqueous solution is a commonly utilized anti-septic employed for sterilization of the ocular surface prior to interventional procedures. Dimethylsulfoxide (DMSO) is a well-known skin penetration agent scarcely utilized in ophthalmic drug formulations. We describe here a low-dose formulation of 1% PVP-I (w/w) in a gel containing DMSO for use in the setting of recalcitrant rosacea blepharoconjunctivitis. A review of the ocular uses of dimethylsulfoxide is also presented.

Case report

A 78-year-old male presented with chronic, long-standing blepharitis involving both the anterior and posterior lid margins. Posterior lid and skin inflammatory changes were consistent with ocular rosacea. Previous oral and topical therapies had been largely ineffective at controlling his condition.

Conclusion

The topical PVP-I/DMSO system was effective in abating the signs and symptoms of rosacea blepharoconjunctivitis. Further investigation of this novel agent is warranted.

Electronic supplementary material

The online version of this article (doi:10.1007/s40123-015-0040-4) contains supplementary material, which is available to authorized users.