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Friday, June 1, 2018

Proof that Black Mold Affects the Body and Causes Dry Eyes: ?

It is hard to find any publications linking Black Mold with Dry Eye, but there are a few showing the relationship with mold and eye irritation. See ** below.

There is an association but it has not been proven thus far.

Here is what the CDC says:
Stachybotrys chartarum (Stachybotrys atra) and other molds may cause health symptoms that are nonspecific. At present there is no test that proves an association between Stachybotrys chartarum (Stachybotrys atra) and particular health symptoms. Individuals with persistent symptoms should see their physician. However, if Stachybotrys chartarum (Stachybotrys atra) or other molds are found in a building, prudent practice recommends that they be removed.

Facts about Stachybotrys chartarum and Other Molds

How do molds affect people?
I heard about “toxic molds” that grow in homes and other buildings. Should I be concerned about a serious health risk to me and my family?
The term “toxic mold” is not accurate. While certain molds are toxigenic, meaning they can produce toxins (specifically mycotoxins), the molds themselves are not toxic, or poisonous. Hazards presented by molds that may produce mycotoxins should be considered the same as other common molds which can grow in your house. There is always a little mold everywhere – in the air and on many surfaces. There are very few reports that toxigenic molds found inside homes can cause unique or rare health conditions such as pulmonary hemorrhage or memory loss. These case reports are rare, and a causal link between the presence of the toxigenic mold and these conditions has not been proven.
In 2004 the Institute of Medicine (IOM) found there was sufficient evidence to link indoor exposure to mold with upper respiratory tract symptoms, cough, and wheeze in otherwise healthy people; with asthma symptoms in people with asthma; and with hypersensitivity pneumonitis in individuals susceptible to that immune-mediated condition. The IOM also found limited or suggestive evidence linking indoor mold exposure and respiratory illness in otherwise healthy children. In 2009, the World Health Organization issued additional guidance, the WHO Guidelines for Indoor Air Quality: Dampness and Mould[PDF – 2.65 MB]. Other recent studies have suggested a potential link of early mold exposure to development of asthma in some children, particularly among children who may be genetically susceptible to asthma development, and that selected interventions that improve housing conditions can reduce morbidity from asthma and respiratory allergies, but more research is needed in this regard.
A common-sense approach should be used for any mold contamination existing inside buildings and homes. The common health concerns from molds include hay fever-like allergic symptoms. Certain individuals with chronic respiratory disease (chronic obstructive pulmonary disorder, asthma) may experience difficulty breathing. Individuals with immune suppression may be at increased risk for infection from molds. If you or your family members have these conditions, a qualified medical clinician should be consulted for diagnosis and treatment. For the most part, one should take routine measures to prevent mold growth in the home.
How common is mold, including Stachybotrys chartarum (also known by its synonym Stachybotrys atra) in buildings?
Molds are very common in buildings and homes and will grow anywhere indoors where there is moisture. The most common indoor molds are Cladosporium, Penicillium, Aspergillus, and Alternaria. We do not have precise information about how often Stachybotrys chartarum is found in buildings and homes. While it is less common than other mold species, it is not rare.
How do molds get in the indoor environment and how do they grow?
Mold spores occur in the indoor and outdoor environments. Mold spores may enter your house from the outside through open doorways, windows, and heating, ventilation, and air conditioning systems with outdoor air intakes. Spores in the air outside also attach themselves to people and animals, making clothing, shoes, bags, and pets convenient vehicles for carrying mold indoors.
When mold spores drop on places where there is excessive moisture, such as where leakage may have occurred in roofs, pipes, walls, plant pots, or where there has been flooding, they will grow. Many building materials provide suitable nutrients that encourage mold to grow. Wet cellulose materials, including paper and paper products, cardboard, ceiling tiles, wood, and wood products, are particularly conducive for the growth of some molds. Other materials such as dust, paints, wallpaper, insulation materials, drywall, carpet, fabric, and upholstery, commonly support mold growth.
What is Stachybotrys chartarum (Stachybotrys atra)?
Stachybotrys chartarum (also known by its synonym Stachybotrys atra) is a greenish-black mold. It can grow on material with a high cellulose and low nitrogen content, such as fiberboard, gypsum board, paper, dust, and lint. Growth occurs when there is moisture from water damage, excessive humidity, water leaks, condensation, water infiltration, or flooding. Constant moisture is required for its growth. It is not necessary, however, to determine what type of mold you may have. All molds should be treated the same with respect to potential health risks and removal.
Are there any circumstances where people should vacate a home or other building because of mold?
These decisions have to be made individually. If you believe you are ill because of exposure to mold in a building, you should consult your physician to determine the appropriate action to take.
Who are the people who are most at risk for health problems associated with exposure to mold?
People with allergies may be more sensitive to molds. People with immune suppression or underlying lung disease are more susceptible to fungal infections.
How do you know if you have a mold problem?
Large mold infestations can usually be seen or smelled.
Does Stachybotrys chartarum (Stachybotrys atra) cause acute idiopathic pulmonary hemorrhage among infants?
To date, a possible association between acute idiopathic pulmonary hemorrhage among infants and Stachybotrys chartarum (Stachybotrys atra) has not been proved. Further studies are needed to determine what causes acute idiopathic hemorrhage.
What if my child has acute idiopathic pulmonary hemorrhage?
Parents should ensure that their children get proper medical treatment.
How do molds affect people?
Some people are sensitive to molds. For these people, exposure to molds can lead to symptoms such as stuffy nose, wheezing, and red or itchy eyes, or skin. Some people, such as those with allergies to molds or with asthma, may have more intense reactions. Severe reactions may occur among workers exposed to large amounts of molds in occupational settings, such as farmers working around moldy hay. Severe reactions may include fever and shortness of breath.
People with a weakened immune system, such as people receiving treatment for cancer, people who have had an organ or stem cell transplant, and people taking medicines that suppress the immune system, are more likely to get mold infections.
Exposure to mold or dampness may also lead to development of asthma in some individuals. Interventions that improve housing conditions can reduce morbidity from asthma and respiratory allergies.
How do you get the molds out of buildings, including homes, schools, and places of employment?
In most cases mold can be removed from hard surfaces by a thorough cleaning with commercial products, soap and water, or a bleach solution of no more than 1 cup of bleach in 1 gallon of water. Absorbent or porous materials like ceiling tiles, drywall, and carpet may have to be thrown away if they become moldy. If you have an extensive amount of mold and you do not think you can manage the cleanup on your own, you may want to contact a professional who has experience in cleaning mold in buildings and homes. It is important to properly clean and dry the area as you can still have an allergic reaction to parts of the dead mold and mold contamination may recur if there is still a source of moisture.
If you choose to use bleach to clean up mold:
  • Never mix bleach with ammonia or other household cleaners. Mixing bleach with ammonia or other cleaning products will produce dangerous, toxic fumes.
  • Open windows and doors to provide fresh air.
  • Wear non-porous gloves and protective eye wear.
  • If the area to be cleaned is more than 10 square feet, consult the U.S. Environmental Protection Agency (EPA) guide titled Mold Remediation in Schools and Commercial Buildings. Although focused on schools and commercial buildings, this document also applies to other building types. You can get it by going to the EPA web site at https://www.epa.gov/mold/mold-remediation-schools-and-commercial-buildings-guide.
  • Always follow the manufacturer’s instructions when using bleach or any other cleaning product.
What should people to do if they determine they have Stachybotrys chartarum (Stachybotrys atra) in their buildings or homes?
Mold growing in homes and buildings, whether it is Stachybotrys chartarum (Stachybotrys atra) or other molds, indicates that there is a problem with water or moisture. This is the first problem that needs to be addressed. Mold growth can be removed from hard surfaces with commercial products, soap and water, or a bleach solution of no more than 1 cup of bleach in 1 gallon of water. Mold in or under carpets typically requires that the carpets be removed. Once mold starts to grow in insulation or wallboard, the only way to deal with the problem is by removal and replacement. We do not believe that one needs to take any different precautions with Stachybotrys chartarum (Stachybotrys atra), than with other molds. In areas where flooding has occurred, prompt drying out of materials and cleaning of walls and other flood-damaged items with commercial products, soap and water, or a bleach solution of no more than 1 cup of bleach in 1 gallon of water is necessary to prevent mold growth. Never mix bleach with ammonia or other household cleaners. If a home has been flooded, it also may be contaminated with sewage. (See: After a Hurricane or Flood: Cleanup of Flood Water) Moldy items should be removed from living areas.
How do you keep mold out of buildings and homes?
As part of routine building maintenance, buildings should be inspected for evidence of water damage and visible mold. The conditions causing mold (such as water leaks, condensation, infiltration, or flooding) should be corrected to prevent mold from growing.
Specific Recommendations:
  • Keep humidity levels as low as you can—no higher than 50%–all day long. An air conditioner or dehumidifier will help you keep the level low. Bear in mind that humidity levels change over the course of a day with changes in the moisture in the air and the air temperature, so you will need to check the humidity levels more than once a day.
  • Use air conditioner or a dehumidifier during humid months.
  • Be sure the home has adequate ventilation, including exhaust fans in kitchen and bathrooms.
  • Use mold inhibitors which can be added to paints.
  • Clean bathroom with mold-killing products.
  • Do not carpet bathrooms.
  • Remove and replace flooded carpets.
I found mold growing in my home; how do I test the mold?
Generally, it is not necessary to identify the species of mold growing in a residence, and CDC does not recommend routine sampling for molds. Current evidence indicates that allergies are the type of diseases most often associated with molds. Since the reaction of individuals can vary greatly either because of the person’s susceptibility or type and amount of mold present, sampling and culturing are not reliable in determining your health risk. If you are susceptible to mold and mold is seen or smelled, there is a potential health risk; therefore, no matter what type of mold is present, you should arrange for its removal. Furthermore, reliable sampling for mold can be expensive, and standards for judging what is and what is not an acceptable or tolerable quantity of mold have not been established.
A qualified environmental lab took samples of the mold in my home and gave me the results. Can CDC interpret these results?
Standards for judging what is an acceptable, tolerable or normal quantity of mold have not been established. If you do decide to pay for environmental sampling for molds, before the work starts, you should ask the consultants who will do the work to establish criteria for interpreting the test results. They should tell you in advance what they will do or what recommendations they will make based on the sampling results. The results of samples taken in your unique situation cannot be interpreted without physical inspection of the contaminated area or without considering the building’s characteristics and the factors that led to the present condition.
Summary
In summary, Stachybotrys chartarum (Stachybotrys atra) and other molds may cause health symptoms that are nonspecific. At present there is no test that proves an association between Stachybotrys chartarum (Stachybotrys atra) and particular health symptoms. Individuals with persistent symptoms should see their physician. However, if Stachybotrys chartarum (Stachybotrys atra) or other molds are found in a building, prudent practice recommends that they be removed.

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Here is a paper noting the association between mold and eye irritation:
. 2003 Jan; 16(1): 144–172.
PMCID: PMC145304
PMID: 12525430

Indoor Mold, Toxigenic Fungi, and Stachybotrys chartarum: Infectious Disease Perspective

D. M. Kuhn1,2,3 and M. A. Ghannoum2,3,*

INTRODUCTION

Damp buildings often have a moldy smell or obvious mold growth, and some molds are known human pathogens. This has caused concern regarding potential health effects of moldy indoor environments. As a result, there have been many studies of moisture- and mold-damaged buildings. More recently, there have been a growing number of articles in the media and of lawsuits claiming severe illness as a result of indoor mold exposure, particularly to Stachybotrys chartarum. However, while many authors report a clear relationship between fungal contaminated indoor environments and illness, close examination of the literature reveals a much more confusing picture.
In this review, we discuss indoor environmental mold exposure and mycotoxicosis, with an emphasis on S. chartarum and its toxins (due to the breadth of the topic, we will not discuss better understood areas such as invasive disease caused by Aspergillus). We also discuss specific organ effects, focusing on illnesses purportedly caused by indoor mold. These illnesses include pulmonary, immunologic, neurologic, and oncologic disorders. We discuss the Cleveland infant idiopathic pulmonary hemorrhage (IPH) reports in some detail, since they provided much of the fuel for current concerns about Stachybotrys exposure. As we will see, while there is cause for concern about the potential effects of indoor mold exposure, particularly to Stachybotrys species, there is no well-substantiated evidence linking the presence of this fungus to health concerns elaborated in the scientific and lay press.
As patients and society at large become increasingly concerned that illnesses may be due to the home or work environment, an understanding of mycotoxins by microbiologists and clinicians (especially infectious-disease subspecialists) is of growing importance. Such knowledge is critical to the diagnosis of potential fungus-related disease and is necessary to assuage fears instilled by extensive media coverage (34; J. MacFarlane, 1997, Beware the mold Stachybotrys, http://www.cnn.com/HEALTH/9711/05/deadly.mold; J. McKenzie, 2001, Hidden menace: insurers worry about toxic mold claims, http://more.abcnews.go.com/sections/wnt/dailynews?toxicmold_010626.html; E. Moriarty, 2000, Invisible killers, OBS News, New York, N.Y.; N. Morris, 2001, Moldy Schools: are your kids getting sick at school? http://more.abcnews.go.com/sections/wnt/WorldNewsTonight/wnt010418_moldyschools_feature.html). Finally, such knowledge may be important in the wake of recent terrorist events in the United States. Some toxins, particularly aflatoxins and trichothecenes, have the potential to be used as weapons. There is evidence that several countries are currently involved in mycotoxin weapon research (, , ). The latter point is beyond the scope of this article.

INDOOR AIR AND BUILDING-RELATED ILLNESS

It has long been postulated that exposure to damp, moldy home and workplace environments has detrimental health effects. At the beginning of the 18th century, Ramazzini, considered “the father of occupational medicine,” described an illness of workers inhaling ‘foul and mischievous powder' from handling crops (, ). More recently, Platt et al. (), found that occupants of wet, moldy buildings had an increase in subjective complaints. Brunekreef et al. () found a similar pattern in >6,000 children in six states in the United States and reported home dampness was a strong predictor of respiratory and other illness in this age group. The list of putative symptoms generally consists of upper respiratory complaints, including headache, eye irritation, epistaxis, nasal and sinus congestion, cough, “cold and flu” symptoms, as well as generalized gastrointestinal complaints (). Taskinen et al. (, ) reported an increased prevalence of asthma in moisture-affected schools, although there were no objective measurements of respiratory disease. A number of studies have reported a relationship between similar symptoms and damp housing or workplace environments, although the proposed etiologies have varied (, , , , , ).
The causal relationship between damp housing and illness is unclear. Establishing such a relationship is complicated since there are a variety of pollutants in the indoor environment () including volatile organic compounds such as toluene, benzene, alkenes, aromatic hydrocarbons, esters, alcohols, aldehydes, and ketones (, , , , , , ); radon (); combustion gases, sulfur dioxide, nitrogen dioxide, carbon dioxide, ozone (, , ); and the essentially ubiquitous formaldehyde (, ). Other items (copy paper) and activities (photocopying and video terminal exposure) have been linked to symptoms (). Other studies have suggested that shade, organic debris, landscaping quality, central electrostatic systems, ventilation rates, temperature, noise levels, dust control compliance, and patient gender may be important (, , , , , , , , , ), as well as the presence of tobacco smoke (, , ). Psychosocial issues may be playing a role in building-related complaints. Several studies have reported that the quality of the work environment, stress, and somaticization may all be significant (, , , , , , , ).
The indoor environment also contains a wide range of microorganisms including bacteria (e.g., Legionellaand other gram-negative species) (), mycobacteria (, ), and molds (), as well as their products, including endotoxins and mycotoxins. There may often be a much higher bacterial load than fungal load (, ).
Most fungi are metabolically active over a broad temperature range (); however, high moisture and relative humidity are required for optimal growth (). The lowest relative humidity supporting mold growth is approximately 75%, although the requirements of Stachybotrys are much higher, around 93% at 25°C (). Increasing temperature and nutritional status of the substrate can lead to lower moisture requirements. Surfaces that are soiled or have susceptible paint or paper do not need to be as damp for mold to develop. While promoting mold growth, moisture itself may be critical in “sick-building syndrome” (SBS) illnesses, since humidity affects mite and ozone levels, as well as off-gassing, salt, and acid formation (). The links between moisture damage, any of these related cofactors, and building-related illnesses are not clear (, , , , ). For example, dust mites are notorious allergic agents and produce many of the upper airway symptoms ascribed to mold exposure or SBS; moreover, they are almost always found in association with mold species (, , ), confounding moisture- and mold-related findings. Gram-negative bacteria, endotoxin, and mycobacteria are found in water-damaged buildings in association with mold (, ). To our knowledge, only one paper has actually reported a lack of association between symptom prevalence and endotoxin, dust mites, or other nonfungal agents (). In moldy office buildings there is an association between microbial contamination and repeated flooding or stagnant pools of water (). Some geographic locales are obviously more likely to be affected than others. For example, 12% of English building stock suffer serious dampness; extrapolation suggested that there were 2.5 million affected dwellings in the United Kingdom but that 60% of these were from condensation rather than overt flooding (; Anonymous, Bldg. Res. Estab. Semin. Proc., 1981). Readers interested in an in-depth review of these issues are referred to the recent comprehensive report by the Institute of Medicine ().

 2001 Nov;16(11):1065-77.

Indoor environmental quality in six commercial office buildings in the midwest United States.

Reynolds SJ1, Black DW, Borin SS, Breuer G, Burmeister LF, Fuortes LJ, Smith TF, Stein MA, Subramanian P, Thorne PS, Whitten P.

Abstract

The aims of this study were to characterize physical, mechanical, and environmental factors influencing indoor environmental quality (IEQ) in commercial office buildings; document occupant perceptions and psychosocial attributes; and evaluate relationships among these parameters. Six large office buildings in metropolitan areas were selected in Iowa, Minnesota, and Nebraska. Comprehensive sampling was conducted over one week in each building, during all four seasons. This paper presents the study methods and selected results from the first round of sampling (November 1996 to April 1997). Air flow and recirculation rates were quite variable, with the proportion of outdoor air provided to occupants ranging from 10 to 79 CFM/person. Carbon dioxide, carbon monoxide, and temperature were within ranges anticipated for nonproblem buildings. Relative humidity was low, ranging from 11.7 to 24.0 percent. Indoor geometric mean concentrations of total volatile organic compounds (TVOCs) ranged from 73 to 235 microg/m3. The most prevalent compounds included xylene, toluene, 2-propanol, limonene, and heptane. Geometric mean formaldehyde concentrations ranged from 1.7 to 13.3 microg/m3, and mean acetaldehyde levels ranged from <3.0 to 7.5 microg/m3. Airborne concentrations of culturable bacteria and fungi were low, with no samples exceeding 150 CFU/m3. Total (direct count) bioaerosols were more variable, ranging from 5010 to 10,700 organisms/m3. Geometric mean endotoxin concentrations ranged from 0.5 to 3.0 EU/m3. Respirable particulates (PM10) were low (14 to 36 microg/m3). Noise levels ranged from 48 to 56 dBA, with mean light values ranging from 200 to 420 lux. Environmental parameters were significantly correlated with each other. The prevalence of upper respiratory symptoms (dry eyes, runny nose), central nervous system symptoms (headache, irritability), and musculoskeletal symptoms (pain/stiffness in shoulders/neck) were elevated compared to other studies using similar questionnaires. Importantly, psychosocial factors were significantly related to increased symptoms in females, while environmental factors were more closely correlated with symptoms in males. Endotoxin concentrations were associated with symptoms in both males and females. These data will help to identify and quantify the relative role of factors that contribute to sick building syndrome. The data collected in this study may also be used to evaluate the effectiveness of current building operation practices, and can be used to prioritize allocations of resources for reduction of risk associated with IEQ complaints.
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