Does eating probiotics make gout worse?

 Does eating probiotics make gout worse?

I am not sure and have to do more research. Some interesting points in the below article:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994919/

A study performed 45 years ago demonstrated that feeding yeast to healthy young individuals elevated serum uric acid,

Saccharomyces boulardii, or S. boulardii, is one type of probiotic out there. But there’s one major difference: it’s not a type of bacteria. It’s a yeast that happens to function like a probiotic in the body. For the past 30 or so years, doctors have recommended it to help patients with diarrhea. It helps to regulate the intestines and protect them from pathogens and other things that can damage the intestinal lining. It also modulates different parts of your immune system and keeps the intestinal barrier function up and running. Doctors have associated defects in the intestinal barrier function with different gastrointestinal diseases.

References:

1. https://pubmed.ncbi.nlm.nih.gov/26142388/

Review

 

. 2015 Aug;99(16):6563-70.

 doi: 10.1007/s00253-015-6776-x. Epub 2015 Jul 4.

Probiotic Saccharomyces cerevisiae strains as biotherapeutic tools: is there room for improvement?

Mariana L Palma 1, Daniel Zamith-Miranda, Flaviano S Martins, Fernando A Bozza, Leonardo Nimrichter, Mônica Montero-Lomeli, Ernesto T A Marques Jr, Bruno Douradinha

Affiliations 

• PMID: 26142388
 
• DOI: 10.1007/s00253-015-6776-x

Abstract

The probiotic yeast Saccharomyces cerevisiae var boulardii is widely used as a low cost and efficient adjuvant against gastrointestinal tract disorders such as inflammatory bowel disease and treatment of several types of diarrhea, both in humans and animals. S. boulardii exerts its protective mechanisms by binding and neutralizing enteric pathogens or their toxins, by reducing inflammation and by inducing the secretion of sIgA. Although several S. cerevisiae strains have proven probiotic potential in both humans and animals, only S. boulardii is currently licensed for use in humans. Recently, some researchers started using S. boulardii as heterologous protein expression systems. Combined with their probiotic activity, the use of these strains as prophylactic and therapeutic proteins carriers might result in a positive combined effort to fight specific diseases. Here, we provide an overview of the current use of S. cerevisiae strains as probiotics and their mechanisms of action. We also discuss their potential to produce molecules with biotherapeutic application and the advantages and hurdles of this approach. Finally, we suggest future directions and alternatives for which the combined effort of specific immunomodulatory effects of probiotic S. cerevisiae strains and ability to express desired foreign genes would find a practical application.

2. https://medicalxpress.com/news/2019-10-short-term-probiotics-regimen-gout-kidney.html

3. https://www.healthline.com/health/what-yeast-is-good-for-the-gut