What is Miebo and Where to get Miebo?

MIEBO, generically known as perfluorohexyloctane, is a novel treatment for dry eye disease, particularly targeting the evaporative component of dry eye due to meibomian gland dysfunction. Here's how it works: 1. Physical Barrier Formation: MIEBO is a semi-fluorinated alkane which forms a liquid barrier on the surface of the eye like a drop of oil. This barrier acts similarly to the natural lipid layer of the tear film, reducing the evaporation of tears from the ocular surface. 2. Stabilization of Tear Film: By creating this barrier, MIEBO stabilizes the tear film, which is crucial because an unstable tear film can lead to symptoms like irritation, burning, and foreign body sensation in dry eye patients. It helps maintain moisture by preventing tears from evaporating too quickly. 3. Non-Aqueous Layer: Unlike traditional eye drops that add water or water-like substances to the eye, MIEBO does not add moisture but rather works by sealing in the moisture that's already there. This is particularly beneficial for those whose dry eye is not due to insufficient tear production but rather to poor retention of the tears on the eye surface. Why MIEBO is Not an Anti-Inflammatory: 1. Mechanism of Action: MIEBO's primary mechanism does not involve altering the inflammatory pathways or reducing inflammation itself. Instead, it physically modifies the tear film dynamics to prevent dry eye symptoms. Traditional anti-inflammatory drugs work by inhibiting pathways like the arachidonic acid pathway or by modulating immune responses to reduce inflammation. 2. Chemical Composition: Perfluorohexyloctane is chemically inert in terms of biological interactions; it does not interact with cellular receptors, enzymes, or other biological molecules that would typically be involved in inflammatory responses. 3. Targeting Symptoms, Not Cause: MIEBO addresses the symptom of tear evaporation rather than the underlying inflammation that might be contributing to dry eye. Inflammation in dry eye can be caused by various factors, including autoimmune processes in conditions like Sjogren’s syndrome or from the irritation caused by the dry eye itself. MIEBO does not directly combat these inflammatory processes. 4. Complementary to Anti-Inflammatories: Because MIEBO does not work by reducing inflammation, it can be used in conjunction with traditional anti-inflammatory treatments like corticosteroids or cyclosporine if inflammation is a significant component of the patient's dry eye condition. This suggests it's not an anti-inflammatory agent but rather a supportive treatment that improves tear film stability. In summary, MIEBO is designed to manage dry eye by creating a physical barrier that reduces tear evaporation, which helps alleviate symptoms directly related to tear film instability rather than addressing inflammation. This makes it a unique therapeutic in the management of dry eye focusing on a different aspect of the condition's pathophysiology. Where to get it: 1. United States: - MIEBO (Perfluorohexyloctane): - GoodRx: Prices start at $748.36 for the most common version with a GoodRx coupon. However, this is subject to change based on location and pharmacy.(https://www.goodrx.com/miebo) - Bausch + Lomb Access Program: Eligible commercially insured patients may pay as little as $0 copay for up to a 30-day supply.(https://www.goodrx.com/miebo) 2. Canada: - Canadian Pharmacy Online: - MIEBO: The cost starts at $249.99 for 3 vials. Shipping fee is a flat rate of $10.00 per order.(https://www.canadapharmacyonline.com/DrugInfo.aspx?name=Miebo7757) - Canadian Pharmacy King: - MIEBO: Available from New Zealand, manufactured by AFT Pharmaceuticals. The exact price wasn't specified, but you can order it from here.(https://www.canadianpharmacyking.com/Drug/Miebo) - Canada Drugs Direct: - MIEBO: Available for purchase, though specific pricing wasn't listed.(https://www.canadadrugsdirect.com/products/miebo-perfluorohexyloctane) 3. New Zealand: - MIEBO (under the brand name Evotears or Novatears): - Over-the-counter, costing around NZ$34.00 for a one-month supply. However, direct purchase links for these alternatives weren't provided in the search results.(https://en.wikipedia.org/wiki/Perfluorohexyloctane) 4. Australia: - MIEBO (under the brand name Evotears or Novatears): - Over-the-counter, costing around A$30 for a one-month supply. Direct purchase links were not provided.(https://en.wikipedia.org/wiki/Perfluorohexyloctane) 5. Europe (General): - MIEBO (under the brand name Evotears, Hylo, or Novatears): - Available over-the-counter in multiple countries, priced around €30 for a one-month supply. we cannot guarantee the sterility of these drops but Patients have shared these websites with us: https://ursapharm.de/en/products/dry-eye-syndrome/hylo-eye-care/evotears/ https://hylo.de/en/products/evotears Note: - The actual availability and pricing can vary based on local regulations, pharmacy markups, or changes in listings. - For direct purchase, you would need to visit the websites mentioned or contact them directly for the most current information. - Some of these medications require a prescription, particularly in the U.S., so ensure you have one before attempting to purchase. Links for Further Information: - Canadian Pharmacy Online: (https://www.canadapharmacyonline.com/DrugInfo.aspx?name=Miebo7757) - Canadian Pharmacy King: (https://www.canadianpharmacyking.com/Drug/Miebo) - Canada Drugs Direct: (https://www.canadadrugsdirect.com/products/miebo-perfluorohexyloctane) - GoodRx: (https://www.goodrx.com/miebo) For more information, Visit the websites directly or contact them.