IPL+RF vs IPL Alone, and RF vs IPL Studies
| Study (Author, Year) | Comparison | Main Findings | Sponsorship Status | Source |
|---|---|---|---|---|
| Chelnis et al., 2023 | IPL+RF vs IPL+MGX (historical control) | IPL+RF resulted in larger improvement in meibomian gland score (mMGS) compared to IPL+MGX alone; OSDI improvement also noted, but not statistically significant | Sponsored (author affil.: Lumenis Be, a manufacturer) | PubMed ID: 37881780 |
| Jang et al., 2023 | IPL alone (different filters) | IPL alone, regardless of filter, significantly improved clinical signs and symptoms in moderate/severe dry eye compared to baseline, with no mention of RF | Not sponsored by dry eye companies (government and university funds) | PMC: 10126147 |
| Chelnis et al., 2023 (from Derm News) |
IPL+RF vs IPL alone | IPL+RF produced a more complete and comprehensive improvement in meibomian gland health, but author discloses consultancy for Lumenis, Horizon Therapeutics, and Soniquence | Sponsored (consultancy to device companies) | MDEdge, April 2023 |
| Reviews/meta-analyses | IPL alone | IPL alone likely results in symptom relief for DED from MGD, but unclear effect as add-on to standard care, and no direct comparison with RF or RF+IPL | Not sponsored (systematic reviews, independent) | PubMed/PMC 2023–2025 |
| Hamza et al., 2023 | RF alone | RF heating improves meibomian gland function and dry eye, but most studies are company-sponsored (Lumenis/Soniquence devices) | Sponsored | Open Ophthalmol J, April 2023 |
Not Sponsored by Dry Companies
- Jang et al., 2023 – IPL alone improves DED/MGD over baseline in a prospective randomized study, shows IPL efficacy without other treatments (PMC: 10126147)
- Multiple meta-analyses/systematic reviews – IPL alone results in symptom relief, but relative efficacy versus RF/combination therapies not established (various PubMed/PMC)
Sponsored by Dry Companies
- Chelnis et al., 2023 – IPL+RF greater improvement in gland scores and OSDI compared to IPL alone, reported in an industry-affiliated study (PubMed ID 37881780)
- RF device studies – RF improves meibomian gland function based on results from company-linked research (Lumenis/Soniquence)
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