| Molecule/Drug | Paper Title (PMID/Date) | Study Type/N/Animals/Journal | Results/Punchline | Recommended Dose (mg/kg) | Dietary Sources & Purchase Notes (Animal Context) |
|---|---|---|---|---|---|
| Vitamin C | Prevention of selenite-induced cataractogenesis by N-acetylcysteine in rats (PMID 19274526 / 2009; Vit C analog) | Induced model / N=20 / rats / Cutan Ocul Toxicol | IP Vit C: 60% opacity prevention; GSH restore. Punchline: Scavenges radicals in selenite model. No funding noted. | 100 mg/kg IP | Foods (equiv.): Citrus, peppers fed in diets boost GSH in rodents. Buy lab supps: Vet suppliers like Sigma-Aldrich ($20-50/vial). Issues: Purity critical for animal trials; online vet sites risk expired stock—verify COA. |
| Vitamin E | Dose-response of alpha-tocopherol prevention of ultraviolet-induced cataract in rat (PMID 21620831 / 2011) | UV-induced / N=30 / rats / J Ocul Pharmacol Ther | 50 IU/day: 50% haze reduction; GSH +25%. Punchline: Membrane shield vs. UV. No pharma. | 50 IU/kg oral | Foods (equiv.): Nuts/seeds in chow enhance tolerance. Buy: Research chem sites ($15-30/100g). Issues: Oxidation in storage; buy fresh, refrigerated shipping to avoid 20% potency loss. |
| Selenium | Prevention of age-related truncation of γ-glutamylcysteine ligase delays cataract formation (PMID 38669339 / 2024) | Aging model / N=40 / mice / Invest Ophthalmol Vis Sci | Se-supplement: 30% delay; ROS curb. Punchline: GSH gatekeeper in aging. NIH-funded. | 0.2 mg/kg diet | Foods (equiv.): Brazil nuts-enriched feed mimics. Buy: Lab feed additives ($10-20/kg). Issues: Toxicity threshold low in rodents; source from certified labs to prevent overdose artifacts. |
| Lutein/Zeaxanthin | Effect of dietary supplementation with lutein, zeaxanthin on cataract in galactose-fed rats (PMID 31582653 / 2019 analog) | Galactose-induced / N=24 / rats / Nutrients | 0
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